Congrats! These are all good suggestions. I have a couple of ??
How many days are you planning to be in Northern California?
Are you a b and b, hotel, or rental house kind of couple? Do you mind moving from place to place, or do you want to hunker down and do day trips?
Here's my first stab, assuming a week stay.
Fly into SF. Spend first night in the City or Sausalito. Go to a musical or play or special dinner.
Day 2 get up early and drive out to Muir Woods/Point Reyes. Have Hog Island Oysters or kayak. (if you love the coast, stay one night in Point Reyes) Drive through Petaluma and check in to the Lodge at Sonoma or Trojan Horse Inn. Eat dinner at El Dorado Kitchen, Cafe La Haye or La Salette on the Plaza. If it is Tuesday, enjoy the Farmers Market.
Day 3 take early morning hike on the overlook trail behind the Plaza. Have breakfast at the SUnflower Cafe or EDK. Shop around plaza until wine tasting time. Have WD hook you up with some good wineries locally. If you'd rather bike, this would be a good day to bike around to the local wineries, Buena Vista, Gun Bun, Ravenswood, Castle, Hiway 12. Save $$$, buy dinner at Sonoma Market, bring back to hotel and hang out by the pool. Reward self with massage (if staying somewhere else, you can have a massagae therapist come to you) before bedtime. Get dessert in the bar at the hotel. There is very little night life in Sonoma during the week, so you aren't missing anything.
Day 4: Check out of Sonoma, head over to Napa. Visit glass blowers in Sonoma before you go. Stop at Artesa, Domaine Chandon, Nicholson Ranch, etc on your way. Hit favorite wineries there. Camp if you have to, but go to dinner at the French Laundry or Ad Hoc. Have splits of wine to save $$$ Stay somewhere close, because you will be drunk and full.
Day 5: Napa, Calistoga wineries. Check into Healdsburg accomodations that night after dinner at Cyrus (only if you don't do French Laundry, they are very $$$).
Day 6: Visit Dry Creek/Russian River area. This might also be a nice bike tour. The Russian River also has kayak rentals. You will have had way too much great food by now, so buy your food at Oakville Grocery on the square and enjoy a picnic there.
Day 7: Drive back down 101. Stop at Golden Gate Bridge. Go to new museum in SF, the California Academy of Sciences.
Feel free to pm with further questions or ideas. If you are more inclined to stay in one place, I would suggest a different plan. Also, there are many cheaper hotel options, but I do like the Lodge at Sonoma. It's a Marriott and if you call now, you might get to use Marriott points.